Trailing the Vikings at home 16-10 with five seconds left, the veteran found rookie wide receiver Sammy Watkins in the end zone for the game-winning touchdown.
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Orton took over for E.J. Manuel after Week 4 and has led the team to comeback victories over the Lions and Vikings, with the lone loss coming on the road against the Patriots.
Orton finished the game 31-of-43 for 283 yards with two touchdowns and one interception.
