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Ragland, a second-round pick out of Alabama, injured himself pursuing running back Reggie Bush toward the sideline on a play during Friday’s practice.
To make matters worse, the Bills were already dealing with the loss of first-round pick Shaq Lawson for at least the first portion of the regular season after he underwent right shoulder surgery this spring.
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Former Bills linebacker Brandon Spikes, who sat out all of last season, and ex-Saints linebacker David Hawthorne were signed as insurance policies Sunday.
On offense, the Bills lost running back Karlos Williams to a suspension for the first four games of the season.
