Kane carried the puck down the left side as teammates Ben Smith and Brandon Saad rushed toward the net, and beat Ryan Miller with a well-placed wrist shot for his 32nd career postseason goal.
Andrew Shaw and Bryan Bickell also scored for defending Stanley Cup champion Chicago, which blew a 2-0 second-period lead. Jonathan Toews had two assists and Corey Crawford made 30 saves.
Game 5 of the best-of-seven series is Friday night in St. Louis.
WATCH: Blackhawks win in OT
Blue Jackets 4, Penguins 3
COLUMBUS, Ohio — Brandon Dubinsky scored with 22.5 seconds left in regulation to force overtime and Nick Foligno's wrist shot just inside the blue line 2:49 into the extra session gave the Columbus Blue Jackets a 4-3 victory over the Pittsburgh Penguins on Wednesday night.
The Blue Jackets overcame a 3-0 deficit for their first home playoff victory in the franchise's 13 seasons, sending the series back to Pittsburgh for Game 5 on Saturday night tied 2-2.
Craig Adams, Chris Kunitz, James Neal scored in a 5:01 span in the first period to stake the Penguins to a 3-0 lead. But Ryan Johansen and Dubinsky each had a goal and an assist and Boone Jenner also scored for Columbus, making only its second postseason trip.
WATCH: Blue Jackets come back from behind
Stars 4, Ducks 2
DALLAS — Cody Eakin and Alex Goligoski scored 1:22 apart on Dallas' first two shots in the third period and the Stars beat top-seeded Anaheim in Game 4 to tie the series 2-2.
Game 5 is Friday night in Anaheim, and Game 6 is Sunday in Dallas.
Even without captain Ryan Getzlaf, a surprise late scratch with an upper-body injury, and healthy scratch Teemu Selane, the Ducks jumped out to a 2-0 lead in the first period on goals by Bryan Allen and Patrick Maroon.
Dallas captain Jaime Benn scored off a faceoff only 27 seconds into the second period, his third goal in the series. Vernon Fiddler tied it at 6:33 of the second.
WATCH: Stars even series at home
