Boston might be the safest place in America on Monday, Patrick said Sunday on the CBS news program "Face the Nation."
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This year's race begins Monday, winding 26.2 miles through surburban streets before ending in Boston.
Officials are striking a balance between more security and maintaining the city's festive spirit, Patrick said. He would not specify the steps being taken to boost security, but said there will be a "considerably more police presence."
Rep. Michael McCaul, R-Texas, chairman of the House Homeland Security Committee, told ABC's "This Week" on Sunday that cameras, police, police dogs and bomb detecting equipment will make Boston "well-fortified."
McCaul said he's concerned about the possibility of a copycat attack.
The April 15, 2013, bombing and its aftermath left four people dead and more than 260 injured. Many victims lost limbs when two explosive-laden pressure cookers ignited seconds apart near the finish line.
Two brothers were pegged as suspects in the blast. Tamerlan Tsarnaev died later in a police shootout. Dzhokhar Tsarnaev was apprehended days later and faces numerous charges in what is labeled a domestic terror incident.
Some of the security measures in place for Monday's 118th running of the Boston Marathon:
— More than 3,500 police officers — double the usual number — will be out along the 26.2-mile course, including undercover officers with special training.
— At least 100 strategically positioned video cameras will monitor the crowds.
— Spectators are asked to carry their belongings in clear plastic bags instead of backpacks.
— Spectators who do bring backpacks will be subject to a search.
— Coolers, quilts and other bulky items are discouraged.
— Security will be especially tight close to the finish line.
— More than 50 observation points will be set up near the finish line to monitor the crowd.
— Unregistered runners known as bandits won’t be allowed to participate.