The cancer is also linked to other diseases, including Epstein Barr virus (EBV), human immunodeficiency virus (HIV), and certain chromosomal abnormalities. Though it’s considered an aggressive form of cancer, Burkitt lymphoma is usually treatable.
Types of Burkitt Lymphoma
The three main types of Burkitt lymphoma include:
Endemic Burkitt lymphoma: The endemic form originates in Africa and is the most common type. Endemic Burkitt lymphoma is rare in areas outside of Africa. Almost all cases of endemic Burkitt lymphoma are closely linked to Epstein Barr virus (EBV), the virus that causes infectious mononucleosis, also known as “mono. ” It is most commonly found in the jaw. Sporadic Burkitt lymphoma: This type is found all over the world. An abdominal tumor is the hallmark sign of sporadic Burkitt lymphoma. Immunodeficiency-related Burkitt lymphoma: This type often develops in people with HIV/AIDS, or in those who have inherited immune deficiency disorders. It can also occur in individuals who take immunosuppressive drugs after an organ transplant.
Symptoms
Burkitt lymphoma is the fastest growing tumor in the human body, so symptoms may surface quickly.
The first sign is swelling of the lymph nodes in the head and neck, which happens rapidly but is typically painless. Swelling and distortion of facial bones is also a symptom of Burkitt lymphoma, specifically in the jaw in its endemic form.
Sporadic Burkitt lymphoma, which is more common in the United States, usually starts in the abdomen, but Burkitt lymphoma can also originate in the nervous system, bowel, kidneys, or reproductive organs.
Some general symptoms of Burkitt lymphoma include:
FeverNight sweatsUnexplained weight lossFatigueShortness of breath
Causes
Researchers don’t know exactly what causes Burkitt lymphoma. However, what is known is that it more commonly affects children, being the most common type of childhood non-Hodgkin lymphoma.
Nausea and vomiting Shortness of breath Irregular heartbeat Cloudy urine Drowsiness Joint pain or discomfort
Sporadic Burkitt lymphoma accounts for 30% of childhood lymphomas in the United States, and endemic Burkitt lymphoma accounts for 30% to 50% of all childhood cancers in Africa.
An EBV infection is closely associated with most cases of endemic Burkitt lymphoma.
Other risk factors include having a disease that compromises the immune system (such as HIV) or living in a region where malaria is common (such as Africa).
Diagnosis
Physicians will likely perform a biopsy to diagnose Burkitt lymphoma, typically of the bone marrow or lymph nodes. This procedure involves removing a small piece of tissue from the body to analyze in a lab. A pathologist can determine if the sample is cancerous, and if so, what type of cancer it is.
During the diagnostic process, other tests may include:
Physical exam CT scan and/or PET scan Chest X-ray Spinal tap Blood tests
Treatment
Burkitt lymphoma is very treatable. However, because it grows so fast, treatment should be started right away. If untreated, this type of cancer can quickly become severe.
Intensive chemotherapy is usually given to treat Burkitt lymphoma. Oncologists may recommend a combination of chemotherapy drugs, including rituximab, a monoclonal antibody therapy that has been shown to improve outcomes and reduce side effects.
If there is no response to chemotherapy treatment, an oncologist may recommend a bone marrow transplant.
Prognosis
The outlook for Burkitt lymphoma is generally positive if treated promptly. More than half of patients with Burkitt lymphoma can be cured with intensive chemotherapy.
Treatment in children with Burkitt lymphoma is particularly favorable. Those with early-stage disease have a long-term survival rate of more than 90%. The survival rate for kids and teens with more advanced Burkitt lymphoma is still positive, at 80% to 90%.
The disease is sometimes more difficult to treat in older adults who can’t tolerate intensive chemotherapy treatments, so outcomes for elderly patients are lower.
The prognosis for patients who experience relapse is usually poor.
Coping
Dealing with a cancer diagnosis can be difficult. Patients with Burkitt lymphoma can help take care of themselves by eating a healthy diet, exercising, and getting enough rest. Caregivers of children with cancer should do the same.
Patients who experience stress as a result of a cancer diagnosis should consider methods to help reduce stress, like meditation, yoga, massage, or writing about their experience.
A Word From Verywell
If you or a loved one has been diagnosed with Burkett lymphoma, you should know treatment is usually successful and patients often achieve complete remission with intensive chemotherapy. Discuss which therapies are best for your particular situation with your oncologist or healthcare provider.
